This is a scientific Thriller movie where a large magnet is installed to steal the highly potent mutagen from the lab in Arctic Circle. PX-41 is the name given to this mutagen. Silas Ramsbottom leader of the Anti Villain League asks Felonious Gru for help to recover this mutagen. Gru is now leading a good life as businessmen and has a family to take care of. Dr. Nefario leaves the job as Gru’s assistant giving reason that the job is no more interesting.
Gru then agrees to find the mutagen and help the undercover AVL member Lucy Wide. They both go to Paradise Shopping Mall in search of the mutagen and present themselves as bakery workers. Gru suspects Eduardo Perez, an owner of Mexican restaurant. In fact he is the famous super-villain who is dead for the world during sky surfing over an active volcano. Gru and Lucy secretly enter into his restaurant to find any evidence of the stolen element. But they can’t find anything suspicious.