Schmidt and Jenko have successfully ran a program named 21 Jump Street before two years. Their program is about to chase and catch narcotics on the street. Now they are planning to run new program “22 Jump Street”. Last time they have followed Ghost – a drug dealer in their area and his team. Their chief Hardy asks them to try again and this time they disguise as college students and try to find the drug supplier with name “WHYPHY”.
This supplier has killed a person who has tried to catch them on camera in the college campus. Jenko quickly mix up with the college students and make good friends named Zook and Rooster. Rooster is the primarily suspected for having some relations with the drug dealer. Soon Jenko starts going with Zook and Rooster for parties and walks. On the other side Schmidt concentrates on an art student named Maya.